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Perit Dial Int 8(4): 277-279 1988
© 1988 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

Comparison of the In Vitro Activity of Daptomycin and Four Other Antimicrobial Agents Against Staphylococci Associated with CAPD Peritonitis

Wendy L. Vaudry1, Claudia Gratton2, Kinga Kowalewska2 and Wanda M. Wenman1

1 Departments of Pediatrics and2 Laboratory Medicine, University of Alberta Hospitals, Edmonton, Alberta, Canada

Correspondence to: Wendy L. Vaudry, Department ofPediatrics, University of Alberta Hospitals, Edmonton, Alberta, Canada T6G 2R7.

The minimum inhibitory concentration (MIC) of daptomycin was compared with that of four other antimicrobial agents against clinically relevant staphylococci. Sixtyfive isolates were obtained from patients on continuous ambulatory peritoneal dialysis (CAPD) who contracted peritonitis. These isolates comprised 29 S. 8ureus strains (all sensitive to oxacillin); 25 S. epldermldis strains (14 sensitive and 9 resistant to oxacillin); and 11 unspeciated coagulase-negative staphylococci (2 sensitive and 11 resistant to oxacillin). All of the oxacillin susceptible strains were inhibited by ≤2 mg/L of the five antibiotics tested. The oxacillin resistant staphylococci were also resistant to cefuroxime and variably resistant to cefamandole, but were uniformly susceptible to both vancomycin and daptomycin. Daptomycin possesses equivalent in vitro activity to vancomycin against strains of S. 8ureus and coagulase negative staphylococci associated with CAPD peritonitis. If vancomycin resistance becomes a significant problem in these patients, and daptomycin is shown to be active against vancomycin resistant organisms, then it would have potential usefulness as an alternative to vancomycin in the treatment of peritonitis caused by multiply-resistant staphylococci.

KEY WORDS: Daptomycin; antimicrobial susceptibility; Staph. aureus; oxacillin; vancomycin; antibiotics.

Received 25 May 1988; accepted 23 June 1988.






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