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Perit Dial Int 8(4): 249-252
1988
© 1988 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

Intraperitoneal Administration of Recombinant Human Erythropoietin in Uremic Animals

Joanne M. Bargman, Andre Breborowicz1, Helen Rodela, Kostas Sombolos and Dimitrios G. Oreopoulos

Toronto Western Hospital, Toronto, Ontario, Canada;1 Dr. Breborowicz was the recipient of a scholarship from the National Kidney Foundation of Canada.

Correspondence to: Joanne Bargman, Toronto Western Hosp ital, 399 Bathurst Street, Suite 7034, E.C.W., Toronto, Ontario, Canada M5T 2S8.

Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or adsorbed) during a prolonged dwell when administered undiluted by dialysate.

KEY WORDS: Erythropoietin; peritoneal transport.

Received 12 July 1988; accepted 6 September 1988.






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