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Peritoneal Absorption of Vancomycin During and After Resolution of Peritonitis in Continuous Ambulatory Peritoneal Dialysis (CAPO) Patients

Divisions of Nephrology and Clinical Pharmacology, Department of Medicine, University of Virginia Hospitals, Charlottesville, Virginia

Correspondence and reprint requests to B. Bastani, Department of Medicine, Mount Sinai Medical Center, 950 North and 12th Street, P.O. Box 342, Milwaukee, Wisconsin 53201.

We studied the absorption of i.p. loading dose of vancomycin (30 mg/kg of body weight) in five continuous ambulatory peritoneal dialysis (CAPD) patients, both at the time of peritonitis and after its resolution. Mean vancomycin absorption after 6 h of i.p. dwell was 74% from inflamed and 51% from noninflamed peritoneum. Mean peritoneal absorption half-Iife of vancomycin was 3.2 and 7.2 h in the inflamed vs. non inflamed peritoneum, respectively.

KEY WORDS: Peritonitis; vancomycin; continuous ambulatory peritoneal dialysis (CAPD); peritoneal dialysis.

Received 8 September 1987; accepted 19 October 1987.

This article has been cited by other articles:

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Copyright © 1988 by Multimed Inc.