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CONTINUOUS MESOTHELIAL INJURY AND REGENERATION DURING LONG TERM PERITONEAL DIAL YSIS

From the Dept. of Nephrology and the Kornach Laboratory for Experimental Nephrology, Central Emek Hospital, Afula, Israel.

This study reconstructs the whole sequence of mesothelial injury and regeneration in patients on longterm peritoneal dialysis. Our observations indicate that peritoneal dialysis induces a process of continuous mesothelial injury and regeneration. New mesothelial cells seem to origi nate from wandering mesothelial cells of the peritoneal fluid, as well as from mesothelial cell precursors localized in the sub-mesothelial connective tissue.

KEY WORDS: Mesothelial injury; mesothelial regeneration.

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