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THE ANTIMICROBIAL IMPLICATIONS OF THE PHARMACOKINETICS OF COTRIMOXAZOLE IN CAPO PATIENTS

From the Services of Microbiology, St. Joseph's Hospital, Hamilton, Ontario L8N 4A6 and Department of Medicine and Pathology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

Cotrimoxazole (TMP/SMX) has been used to treat continuous ambulatory peritoneal dialysis (CAPD) associated peritonitis. It is considered bactericidal for some species. The most common single organism responsible for this type of peritonitis is Staph. epidermidis (SE). When the drug is given orally, the typical ratio ofTMP to SMX achieved in the peritoneal fluid is 1:5, which is different from the optimal combination for antimicrobial synergy of 1:19. This study investigated the antimicrobial activity of TMP alone and TMP/SMX by agar dilution at ratios of1:19, 1:10and 1:5 against 99 strains of Staphylococcus epidermis (SE). The majority of strains were susceptible to TMP and to all ratios of TMP/SMX by the routine agar dilution methods. We studied the bactericidal activity of TMP/SMX against one strain each of SE and of Staph. aureus (SA) in pooled uninfected spent dialysate by killing curve experiments. TMP at concentrations of 0.5 to 2.0 μg/ml was bacteriostatic. TMP/SMX became slowly bactericidal when 5 % lysed horse blood, a source of thymidine phosphorylase, was added to the dialysate.

KEY WORDS: CAPD; Dialysate; Peritonitis; Cotimoxazole; Antimicrobials.

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