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Perit Dial Int 7(1): 6-9 1987
© 1987 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

MECHANISM OF PHOSPHATIDYLCHOLINE ACTION DURING PERITONEAL DIAL YSIS

Andrzej Breborowicz, Kostas Sombolos, Helen Rodela, Raymond Ogilvie, Joanne Bargman and Dimitrios Oreopoulos

From the Departments of Medicine and Biochemistry, Toronto Western Hospital and University of Toronto.

We studied the effect of phosphatidylcholine (PDC) (50 mg/L) on the peritoneal ultrafiltration and permeability in vivo and in vitro. Our in vivo studies with normal rabbits confirmed previous observations of increased ultrafiltration mainly by decreasing the reabsorption phase. We observed no effect on glucose absorption rate. In in vitro studies, using isolated section of rabbit's mesentery, phosphatidylcholine in creased the permeability of the mesothelium to water, urea and glucose from the vascular to the mesothelial side but not in the opposite direction. Following exposure of the peritoneal membrane to Alcian blue, a positively charged dye, phosphatidylcholine had no effect on mesothelial permeability.

KEY WORDS: Phosphatidylcholine; ultrafiltration; Mesothelium.






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