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Perit Dial Int 6(3): 141-143 1986
© 1986 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

EXAGGERATED PROTEIN LOSS COMPLICATING STERILE PERITONITIS RESUL TS FROM INCREASED DIFFUSION

Przemyslaw Hirszel, Eva Chakrabarti and John F. Maher

From the Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 208144799.

To assess the mechanism of protein loss during chemical peritonitis, dialyses with sodium desoxycholate added to the instilled solution were compared to controls in rabbits. Sodium desoxycholate caused an inflammatory reaction characterized by increased protein loss, leukocyte exudation, decreased ultrafiltration and increased clearance of solutes including neutral dextrans. It is suggested that increased protein loss accompanying peritonitis which is due to increased diffusion through capillaries unrelated to effects of membrane anionic charge. Exaggerated protein loss is a recognized sequel of the peritonitis that complicates peritoneal dialysis (I, 2). Such excessive protein loss can contribute to malnutrition, impeding recovery from infection.






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