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Perit Dial Int 6(1): 6-9 1986
© 1986 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

REACTIVATION OF SYSTEMIC LUPUS IN THREE PATIENTS UNDERGOING CAPD

George G. Wu*, D.R. Gelbart**, James A. Hasbargen***, Robert Inman*, Peter McNamee* and Dimitrios G. Oreopoulos*

Division of Nephrology, Toronto Western Hospital* , Dominican Santa Cruz Hospital** , and The Fit7Simon's AnDy Medical Centre*** .

Generally patients with end-stage renal disease (ESRD) due to lupus nephritis, have minimal extrarenal disease activity <Juring hemodialysis. This may be related to immunological changes secondary to chronic renal failure or the dialysis procedure itself, or both. This paper describes three patients with lupus nephritis undergoing continuous ambulatory peritoneal dialysis (CAPD) in whom we observed reactivation of SLE, by both clinical and serological criteria. This may suggest that in patients undergoing CAPD the immune system is more nearly intact than in hemodialysis. These cases should heighten awareness that patients may suffer flare-ups of SLE during CAPD even long after the onset of renal failure.

KEY WORDS: Systemic lupus erythematosus; Collagen disease; Immune system.






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