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REVIEWS AND ORIGINAL ARTICLES |
From the Department of Nephrology, Odense University Hospital. Hospital Pharmacy, Odense University Hospital. Department of Clinical Chemistry, Svendborg Hospital. Department of Clinical Chemistry, Aalborg Hospital.
For three months we alternately used CAPD solutions based on amino acids or
glucose in six patients. At the start, amino acid concentrations in plasma (P)
were normal, except that for leucine which was low and citrulline was high.
During the study, P-valine, - isoleucine, -leucine, and -serine increased
while the concentration of methionine decreased. The increase in the plasma
concentration of the three branched-chain amino acids might increase protein
synthesis; leucine particularly assists protein synthesis in muscle. However
the technical and analytical methods used in this investigation do not permit
us to draw such conclusions. Serum concentrations of cholesterol, HDL, LDL,
glucose and glycosylated hemoglobin remained unchanged, as did concentrations
of albumin, transferrin, and phosphate. The nitrogen load from amino acids did
not increase the plasma ammonium concentration, while serum urea increased
slightly. Serum triglycerides continued to increase in spite of the amino acid
supplementation. Thus the amino acid solution, which was well tolerated,
seemed to induce some beneficial alterations in the plasma amino acid
concentrations in the uremic patient. The consequence of these changes remains
to be evaluated.
KEY WORDS: Amino acids; CAPD solutions; Nutrition; Triglycerides; Choles terol.
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