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REDUPLICATED BASAL LAMINA OF SMALL VENULES AND MESOTHELIUM OF HUMAN PARIETAL PERITONEUM: Ultrastructural Changes of Reduplicated Peritoneal Basement Membrane

From the Department of Nephrology and the Kornach Laboratory for Experimental Nephrology .Central Emek Hospital, Afula Israel.

We examined under the electron microscope samples of parietal peritoneum obtained from nine nondiabetic chronic uremics -six of them on maintenance intermittent peritoneal dialysis, ranging in age from 52 to 82 years -mean 64.4 ± 8.1 years and of nine non-uremic, non-diabetic patients -mean age 40.7 ± 12.2 years. Postcapillary venules and small venules showed areas with several layers of reduplicated basal lamina. Some microves sels showed gaps in basallamina with and/or without focal reduplication. Reduplicated submesothelial basal lamina was found in only one patient. These changes were not observed in the nine non-uremic, non-diabetic controls. To the best of our knowledge, this is the first description in humans of such alterations in the aforementioned locations, which may well be secondary to aging and/or to the intense mesothelial renewal observed in I.P.D. patients. We need to determine the possible influence of these ultrastructural changes on transperitoneal transfer of water and solutes during peritoneal dialysis.

KEY WORDS: Aging; Peritoneum; Peritoneal dialysis; Basal lamina; Peritoneal ultrastructure.

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