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THE ASSESSMENT OF PERITONEAL FUNCTION USING A SINGLE HYPERTONIC EXCHANGE

From the Departments of Medicine and Clinical Biochemistry, Freeman Hospital and the Royal Victoria Infirmary, Newcastle upon Tyne, England, U.K.

Peritoneal ultrafiltration, creatinine clearance and glucose absorption were measured in 56 CAPD patients using a single hypertonic exchange with a four-hour dwell. The intraindividual coefficient of variation for these parameters was less than 5 % and the results obtained correlated significantly with those obtained using a six-hour dwell. Ultrafiltration capacity was independent of clearance values but glucose absorption correlated directly with clearance and inversely with ultrafiltration levels (p < 0.001). Multiple regres sion analysis showed a decline in four-hour clearance values with time on CAPD (p < 0.001), and an increase in glucose absorption after four hours with Frezenius hypertonic solution (p < 0.02) but no other effect of patient age, sex, body surface area, serum albumin, duration of CAPD treatment, peritonitis history or dialysate brand on these indices of peritoneal function. It is important to monitor peritoneal function in patients treated by CAPD and these results indicate that a single, timed, hypertonic exchange is a reproducible test of ultrafiltration, clearance and glucose absorption.

KEY WORDS: CAPD; ultrafiltration; clearance; glucose absorption.

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