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EFFECT OF THE PERITONEAL DIALYSATE BUFFER ON ULTRAFILTRATION: STUDIES IN NORMAL RABBITS

From the Division of Nephrology, Toronto Western Hospital and Department of Medicine, University of Toronto.

We studied an animal model to test the ultrafiltration capability of three different peritoneal dialysis solutions: Brand A, containing lactate and manufactured in Canada, Brand B, containing acetate and manufactured in U.S.A. and Brand C also containing acetate and manufactured in France. Solutions with 1.5 g0/o and 4.25 g0/o glucose concentrations were tested. We found no significant difference in the amount of ultrafiltration produced with the three brands when glucose concentration was 1.5 g0/o. However with glucose concentration of 4.25 g 0/o ultrafIltration was significantly lower with the Brand C-French acetate solution comparing to Brand A-Iactate solution. Brand B (acetate U.S.A.) solution produced ultrafiltration volumes that were between the other two and were not statistically significantly different from either Brand A (acetate) nor from Brand C (acetate).

We concluded that the lower ultrafiltration produced by Brand C is not due to the presence of acetate buffer but to other factors operating alone or in combination with acetate.

KEY WORDS: Lactate-buffer; acetatebuffer; ultrafiltration; peritoneal dialysis.

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