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Perit Dial Int 5(2): 105-108 1985
© 1985 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

INTRACELLULAR CALCIUM IONS MODULATE PERMEABILITY OF THE PERITONEAL MESOTHELIUM IN VITRO*

Andrzej Breborowicz, Jan Knapowski and Grzegorz Breborowicz

From the Department or Pathophysiology, Medical Academy, 60-781 Poznan, Poland, ul. Swiecickiego 6.

The authors studied the in vitro effect of a calcium-channel-blocker -verapamil, local anesthetic -bupivacaine and a calcium ionophore -A23187 on the permeability of the monolayer mesothelium from the rabbit's mesentery. Verapamil and bupivacaine increased transmesothelial flux of calcium while A23187 [GenBank] increased calcium transport only transiently. Verapamil augmented the permeability of the mesothelium to inulin and urea. However A23187 [GenBank] decreased the transmesothelial flux of inulin only whereas it increased the transport of urea. From this study we have concluded, that intracellular calcium may determine the permeability of the peritoneal mesothelium.

KEY WORDS: Peritoneal mesothelium; study in vitro; intracellullar calcium; solutes transport.






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