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REVIEWS AND ORIGINAL ARTICLES |
From the Divisions of Nephrology and Neurology, Toronto Western Hospital and Department of Medicine, University of Toronto
The authors studied electrophyhsiological parameters in 29 patients (23
non-diabetics, six diabetics, mean age 47.9, range 16-74 yr.), who had been on
CAPD for three to five years. The parameters studied were: motor nerve
conduction velocities of the median, ulnar, and peroneal nerves, and sensory
nerve conduction velocities of the median and ulnar nerves. These parameters
were measured before or within the first month of CAPD and every six months
thereafter. The changes in nerve conduction velocities were studied using
simple linear regression analysis, and calculating the differences of the
slopes from zero. Comparison of the mean values of the conduction velocities
in non-diabetics at the beginning of CAPD and in age-matched, nonuremic
patients showed significantly (p < 0.001) lower values in all parameters
measured. The initial nerve conduction velocities in diabetic patients were
significantly (p < 0.01) slower than in non-diabetics except sensory
conduction velocity of the ulnar nerve. The slopes of nerve conduction
velocities plotted against time were not significantly different from zero for
any nerve in both non-diabetics and diabetic patients. In conclusion, no
significant change in peripheral nerve function was seen after long term CAPD
in either diabetic or non-diabetic patients.
KEY WORDS: Neuropathy; CAPD; Complications; Uremic Neuropathy.
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