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Perit Dial Int 5(1): 19-24 1985
© 1985 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

A RANDOMIZED MULTICENTER CLINICAL TRIAL TO EVALUATE THE EFFECTS OF AN ULTRAVIOLET GERMICIDAL SYSTEM ON PERITONITIS RATE IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS

K.D. Nolph, M.D., B. Prowant, R.N., K.D. Serkes, M.D., L.M. Morgan, R.N., W .K. Pyle, Ph.D., M.P. Hiatt, B.S., J. E. Grant, J. W. Moncrief, M.D., C. V. Mullins-Blackson, R.N., C. Chary tan, M.D., T. Leggio, R.N., R.A. Gutman, M.D., A.G. Edwards, R.N., R.J. Hamburger, M.D., S.A. Kleit, M.D., J. McGuinness, R.N., C.R. Schleifer, M.D., M.C. Cupit, R.N., F. Husserl, M.D., N. Pascual, R.N., C.A. Feldman, M.D., M.L. Oppenheimer, R.N., C. Elwood, R.N., Z.J. Twardowski, M.D., L.P. Ryan, R.N., G. Morrison, M.D., C.M. Morfitt, R.N., S. W. Zimmerman, M.D., M. O'Brien, R.N., J.C. Weldon, R.N. A MULTICENTER STUDY GROUP*

* Clinical Coordinators University of Missauri, Calumbia. Missauri TravenalLabs, Inc., Deeifield, Illinais Data Coordinators University afTexas, Austin, Texas Participating Centers Acarn Research Laborataries. Austin, Texas Booth Memorial Medical Center, New Yark, New Yark Duke University Medical Center, Durham, Narth Caralina Indiana University Medical Center, Indianapalis, Indiana Lankenau Hospital, Philadelphia, Pennsylvania Ochsner Dialysis Clinic, ew Orleans, Lauisiana tellite Dialysis Center, Inc., Palo Alto, Califarnia University af Missauri & Dialysis Clinics, Inc., Calumbia, Missauri University af Pennsylvania, Philadelphia, Pennsylvania University af Wisconsin Haspital. Madisan, Wiscansin

In continuous ambulatory peritoneal dialysis (CAPD), peritonitis frequently is assumed to result from spike contamination during bag exchanges. An ultraviolet germicidal chamber has been developed, which disinfects the spike and the solution-bag outlet before spike insertion. This report summarizes the results of a multicenter trial carried out to determine if this device reduces the incidence of peritonitis in patients on CAPD. Ten centers contributed 167 patients who were followed during a base-line historical control period for a minimum of four months. Thereafter, 93 patients were randomized to a control group, and 74 to the test group. After an interim period for retraining (both groups) and change over (test group), a trial period of nine months was undertaken. Perito nitis rates and actuarial analyses of time-to-peritonitis showed no significant differences between historical and trial periods in either group, or between groups during either period. In both groups, rates of peritonitis were consistently lower than rates reported in the National Registry. The results suggest that, in the patients participating in these studies, spike contamination may have been an infrequent cause of peritonitis.

KEY WORDS: Peritoneal dialysis; ultraviolet light; peritonitis; dialysis; continuous ambulatory peritoneal dialysis.






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