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Perit Dial Int 4(4): 237-239 1984
© 1984 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

DOES HYPERCOAGULABILITY EXIST IN CAPD PATIENTS?

Massimo Bertoli, Maria L. Gasparotto, Ugo Vertolli, Annamaria Ruffatti, Domenico Di Landro and Gian Franco Romagnoli

From the Department or Nephrology - Hospital or Padova, Italy.

Blood levels of fibrinogen degradation products (FDP), factor VIII (antigen and coagulant), plasminogen and antithrombin III, as well as fibrinogen half-life were studied in 15 patients on CAPD from 3-24 months; the daily loss of these factors in the dialysate was also determined.

Fibrinogen and factor VIII levels were above (p < 0.05), fibrinogen half-life was below (p < 0.05) and AT III was within the normal range. The average daily protein loss in the dialysate was 7.74:t 2.42 g; fibrinogen loss was48.14:t 41.66 mg;FDP241.37:t 185.19 mg; plasminogen 11.16:t 6.94, and AT IIl64.96:t 37.67 mg.

These findings suggest that patients on CAPD have a state ofhypercoagulability similar to that observed in patients with the nephrotic syndrome.

KEY WORDS: Hypercoagulability; CAPD; factor VIII; fibrinogen.






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