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REVIEWS AND ORIGINAL ARTICLES |
Medical Nephrology Institute of the University. Nephrology and Dialysis Department, San Giovanni Hospital, Turin, Italy.
T -cell subsets were classified by monoclonal antibodies (OKT3 -peripheral
mature T cells; OKT4 helper/inducer; OKT8 -cytotoxic/ suppressor) in CAPD and
hemodialysis patients. Data were compared with in vivo assays of T cell
function, such as DNCB and PPD skin tests.
Uremic patients had significant absolute lymphopenia; when the results were
expressed as a percentage of OKT3+ cells, they did not differ from the
controls. When they suffered from peritonitis, CAPD patients showed an
increase in OKT8+ cells, but the ratio ocOKT4+ cells to OKT8+ cells showed no
significant deviation from the normal population. On the other hand, CAPD
patients showed a better response to DNCB and PPD antigens. In the
hemodialysis patients there was a significant correlation between the negative
response to the DNCB test and blood transfusion. There was no correlation
between the immune response and the primary disease, or the nutritional status
in either groups.
KEY WORDS: Cell mediated Immunity; CAPD vs Hemodialysis; Infections; Peritonitis.
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