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Perit Dial Int 4(1): 23-26 1984
© 1984 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

INSULIN DELIVERY FROM CONTINUOUS AMBULATORY PERITONEAL DIALYSIS BAGS USED WITH PERIDEX FILTERS

Marcia R. Silver and Michael I. Sorkin

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine.

We studied the percent delivery of insulin from CAPD dialysis solution bags used with and without the Peridex bacteriological filter. The studies were done in vitro using 125I trace.labelled insulin. The data demonstrate that most of the insulin added to bags of dialysis solution during CAPD is delivered into the peritoneal cavity. The mean (± S.D.) amount of insulin delivered for the trials without filters was 99 (± 5) %. For the group with filters, the mean was 75 (± 8)%. The difference was statistically significant (P < 0.001). Also, a statistically significant (P < 0.03) difference was observed be tween the data from the first three uses of new tubing sets versus subsequent uses.

We conclude that the insulin prescriptions of most diabetics will not require alteration when they change from CAPD without a Peridex filter to CAPD with the filter.

KEY WORDS: insulin delivery in CAPD; CAPD; bacteriological filters.







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