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REVIEWS AND ORIGINAL ARTICLES |
Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine.
We studied the percent delivery of insulin from CAPD dialysis solution bags
used with and without the Peridex bacteriological filter. The studies were
done in vitro using 125I trace.labelled insulin. The data demonstrate
that most of the insulin added to bags of dialysis solution during CAPD is
delivered into the peritoneal cavity. The mean (± S.D.) amount of
insulin delivered for the trials without filters was 99 (± 5) %. For
the group with filters, the mean was 75 (± 8)%. The difference was
statistically significant (P < 0.001). Also, a statistically significant (P
< 0.03) difference was observed be tween the data from the first three uses
of new tubing sets versus subsequent uses.
We conclude that the insulin prescriptions of most diabetics will not
require alteration when they change from CAPD without a Peridex filter to CAPD
with the filter.
KEY WORDS: insulin delivery in CAPD; CAPD; bacteriological filters.
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