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EVALUATION OF THYROID FUNCTION IN PATIENTS TREATED WITH CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD)

^* Servicio de Nefrologia,^** Servicio de Endocrinologia,^*** Dpto. Laboratorio, C.S.S.S. La Paz, Madrid, Spain

Abnormal thyroid function has been described in chronic renal insufficiency, and further changes occur with increasing time on hemodialysis. This study on two groups of patients was done to determine whether treatment with CAPD induces changes in thyroid function. Group A included 16 patients with an average duration of treatment of 2.1 ± 1.1 months; group B included 12 patients with 8.1 ± 2 months. We measured total T4 and T3, free T4, TBG, RT3U, FTI, T4/T3 and basal TSH, and TSH induced by TRH stimulation in plasma, and total and free T4 in dialysate. The results showed a significant decrease in total T4 and T3 in plasma, but no change in free T4 or TSH and no appreciable amounts of the hormones in the dialysate. We believe the decrease in total T4 and T3 is secondary to alterations in transport proteins while thyroid function is maintained by normal free T4 and TSH levels more dependable parameters for the interpretation of thyroid function in chronic diseases.

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