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Perit Dial Int 3(1): 15-16 1983
© 1983 International Society for Peritoneal Dialysis
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REVIEWS AND ORIGINAL ARTICLES

LIFE THREATENING HYPERKALEMIA ASSOCIATED WITH CLOFIBRATE-INDUCED MYOPATHY IN A CAPD PATIENT

Walter Demedts*, Jean Pierre Desager**, Frans Belpaire***, Severin Ringoir* and Norbert Lameire*

* University Hospital, Renal Division, Department of Medicine, De Pintelaan 185, B-9000 Gent, Belgium** Universite Catholique de Louvain, Department de Pharmaco-therapie, Av. Mounier, 53, B-1200 Brussels, Belgium*** University Hospital, Heymans Institute of Pharmacology, De pintelaan, 185, B-9000 Gent, Belgium

A man being treated with CAPD developed severe hyperkalemia associated with clofibrate-induced rhabdomyolysis. A total intake of9.5 9 of clofibrate was complicated by a 100 fold increase of CPK, a dramatic increase in muscular enzymes and a life-threatening serum K level of 7.9 mEq/l. Despite a significant peritoneal elimination of clofibrate, this man exhibited a supranormal serum level of free drug.






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