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Perit Dial Int 29(Supplement_2): 49-50
2009
© 2009 International Society for Peritoneal Dialysis
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Part 2: Cellular and Molecular Biology of the Peritoneum and Peritoneal Dialysis

AN EXPERIMENTAL MODEL OF ENCAPSULATING PERITONEAL SCLEROSIS

Tokihiko Sawada1, Yasuo Ishii2, Ichiro Nakajima2, Shohei Fuchinoue2, Keiichi Kubota1 and Satoshi Teraoka2

Second Department of Surgery1 Dokkyo University School of Medicine, Mibu; Department of Surgery2 Kidney Center, Tokyo Women's Medical University, Tokyo, Japan

Correspondence to: T. Sawada, Second Department of Surgery, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321-0293, Japan. tsawada{at}dokkyomed.ac.jp

In Japan, only about 3% of all patients with end-stage renal disease are maintained by continuous ambulatory peritoneal dialysis (CAPD). Although the reasons for the low proportion of patients receiving CAPD are multifactorial, encapsulating peritoneal sclerosis (EPS), a fatal complication of CAPD, is a major factor. In 1995 we developed a rat model of EPS, and in 2001 also developed an EPS model in mice. These rodent EPS models are reliable, reproducible, and inexpensive and have been used by other investigators. The renin–angiotensin system negatively regulates the transforming growth factor-beta signaling pathway, which plays a major role in tissue fibrosis. To investigate the anti-EPS effect of renin–angiotensin system inhibition, an angiotensin-converting enzyme inhibitor, quinapril, was administered to an EPS model in mice. Quinapril was found to inhibit EPS, both macro- and microscopically, in a dose-dependent manner. We report our experience of developing the experimental in vivo EPS model, and the inhibitory effect of this angiotensin-converting enzyme inhibitor on EPS.

KEY WORDS: Encapsulating peritoneal sclerosis; angiotensin-converting enzyme inhibitor; quinapril; mouse model.






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