HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rippe, B. Search for Related Content PubMed PubMed Citation Articles by Rippe, B.

HOW TO ASSESS TRANSPORT IN ANIMALS?

Department of Nephrology, University Hospital of Lund, Sweden

Correspondence to: B. Rippe, Department of Nephrology, Lund University, University Hospital of Lund, S-211 85 Lund, Sweden. Bengt.Rippe{at}med.lu.se

The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different species. Although animal models only partly mimic human peritoneal dialysis, they are valuable tools for understanding the basic physiology and biology of peritoneal dialysis.

KEY WORDS: Capillary permeability; mouse; rat; transcytosis; aquaporin-1.

Copyright © 2009 by Multimed Inc.