PDI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Perit Dial Int 29(6): 605-617
2009
© 2009 International Society for Peritoneal Dialysis
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Schilte, M. N.
Right arrow Articles by van den Born, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schilte, M. N.
Right arrow Articles by van den Born, J.

REVIEW

FACTORS CONTRIBUTING TO PERITONEAL TISSUE REMODELING IN PERITONEAL DIALYSIS

Margot N. Schilte1, Johanna W.A.M Celie1, Piet M. ter Wee2, Robert H.J. Beelen1 and Jacob van den Born1,a

Departments of Molecular Cell Biology and Immunology1 and Nephrology,2 VU University Medical Center, Amsterdam, The Netherlands

FOOTNOTES

a Now at: Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.

Correspondence to: M.N. Schilte, Department of Molecular Cell Biology and Immunology, H269, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. m.schilte{at}vumc.nl

ABSTRACT

Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this review we describe factors contributing to peritoneal tissue remodeling, including uremia, peritonitis, volume loading, the presence of a catheter, and the PD fluid itself. These factors initiate recruitment and activation of peritoneal cells such as macrophages and mast cells, as well as activation of peritoneal cells, including mesothelial cells, fibroblasts, and endothelial cells. We provide an overview of cytokines, growth factors, and other mediators involved in PD-associated changes. Activation of downstream pathways of cellular modulators can induce peritoneal tissue remodeling, leading to ultrafiltration loss. Identification of molecular pathways, cells, and cytokines involved in the development of angiogenesis, fibrosis, and membrane failure may lead to innovative therapeutic strategies that can protect the peritoneal membrane from the consequences of long-term PD.

KEY WORDS: Cytokines; peritoneal cells; peritoneal rest; therapeutic interventions; tissue remodeling.

Received 24 October 2008; accepted 3 February 2009.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Multimed Inc. logo
Copyright © 2009 by Multimed Inc.