PDI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Perit Dial Int 29(5): 568-574
2009
© 2009 International Society for Peritoneal Dialysis
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hubalewska–Dydejczyk, A.
Right arrow Articles by Sulowicz, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hubalewska–Dydejczyk, A.
Right arrow Articles by Sulowicz, W.

Clinical Sciences

IDENTIFICATION OF INFLAMED ATHEROSCLEROTIC PLAQUE USING 123I-LABELED INTERLEUKIN-2 SCINTIGRAPHY IN HIGH-RISK PERITONEAL DIALYSIS PATIENTS: A PILOT STUDY

Alicja Hubalewska–Dydejczyk1, Tomasz Stompór2, Marta Kalembkiewicz1, Marcin Krzanowski2, Renata Mikolajczak3, Anna Sowa–Staszczak1, Barbara Tabor–Ciepiela2, Urszula Karczmarczyk4, Beata Kusnierz–Cabala5 and Wladyslaw Sulowicz2

Nuclear Medicine Unit,1 Department of Endocrinology; Department of Nephrology,2 Jagiellonian University Medical School, Cracow; Radioisotope Centre POLATOM,3 Institute of Atomic Energy, Otwock–Swierk; Department of Radiopharmaceuticals,4 National Medicines Institute, Warsaw; Clinical Biochemistry,5 Jagiellonian University Medical School, Cracow, Poland

Correspondence to: T. Stompór, Department of Nephrology, Jagiellonian University, 15c Kopernika Str., 31-501 Cracow, Poland. stompin{at}mp.pl

{diamondsuit} Background: Patients with end-stage renal disease (ESRD) suffer from markedly increased cardiovascular morbidity and mortality. Common carotid artery (CCA) intima-media thickness (IMT) assessment and CCA plaque identification using ultrasound are well-recognized tools for identification and monitoring of atherosclerosis. A new method for monitoring the inflammatory status of plaque, namely radiolabeled interleukin-2 (IL-2) scintigraphy, was proposed recently. The aim of this pilot study was to perform 123I-labeled-IL-2 carotid plaque scintigraphy in ESRD patients treated with peritoneal dialysis and to correlate obtained results with ultrasound assessment of CCA and selected inflammatory markers.

{diamondsuit} Methods: CCA-IMT was measured and CCA plaques were identified by ultrasound in 10 patients (5 women, 5 men; mean age 62.4 ± 10.4 years; median peritoneal dialysis duration 32.5 months, range 12 – 55 months) with advanced cardiovascular comorbidity. Following CCA ultrasound, 123I-labeled IL-2 carotid plaque scintigraphy was performed. Several biomarkers of inflammation and atherosclerosis were also measured in all patients.

{diamondsuit} Results: Mean target/non-target ratio for focal 123I-IL-2 uptake within the plaque was 3.15 ± 0.54, and mean IMT from the site of the scintigraphy analysis was 0.975 ± 0.337 mm. Highly significant correlation was found between CCA-IMT and a target/non-target ratio for focal 123I-IL-2 uptake in a corresponding artery (R = 0.92, p = 0.01). However, no significant correlations were found between target/non-target ratio for focal 123I-IL-2 uptake and levels of measured biomarkers.

{diamondsuit} Conclusions: Our preliminary results suggest potential for identification of an inflamed (vulnerable) plaque using IL-2 scintigraphy in ESRD patients with cardiovascular comorbidities.

KEY WORDS: Atherosclerosis; atherosclerotic plaque; 123I-interleukin-2 plaque scintigraphy; intima-media thickness.

Received 12 February 2008; accepted 15 October 2008.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Multimed Inc. logo
Copyright © 2009 by Multimed Inc.