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Perit Dial Int 29(2): 171-177
2009
© 2009 International Society for Peritoneal Dialysis
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Clinical

OXIDATIVE STRESS IN CHILDREN ON PERITONEAL DIALYSIS

Danuta Zwolinska1, Wladyslaw Grzeszczak2, Maria Szczepanska3, Irena Makulska1, Katarzyna Kilis–Pstrusinska1 and Krystyna Szprynger3

Department of Paediatric Nephrology,1 Wroclaw Medical University, Wroclaw; Department of Internal Medicine, Diabetology and Nephrology2 ; Dialysis Division for Children,3 Department and Clinic of Pediatrics, Medical University of Silesia, Zabrze, Poland

Correspondence to: D. Zwolinska, Department of Paediatric Nephrology, Wroclaw Medical University, ul. M. Sklodowskiej-Curie 50/52, 50-369 Wroclaw, Poland. nefped{at}nefped.am.wroc.pl

{diamondsuit} Objectives: Enhanced oxidative stress has been observed in dialysis and predialysis adult patients with chronic kidney disease (CKD), which resulted in increased mortality and morbidity within this population. Not much attention in the literature has been paid to nonenzymatic antioxidant defense in children with CKD on peritoneal dialysis (PD). The aim of the present study was to describe the plasma, erythrocyte, and dialysate concentrations of oxidized (GSSG) and reduced glutathione (GSH) and vitamins A, E, and C in a pediatric PD population.

{diamondsuit} Patients: 10 children on PD and 27 age-matched healthy subjects were enrolled in the study.

{diamondsuit} Results: Erythrocyte and plasma GSH concentrations were lower in PD patients, erythrocyte concentration of GSSG remained unchanged, and plasma GSSG was significantly higher in children on PD. Children on PD exhibited decreased plasma concentrations of antioxidant vitamins compared to healthy subjects. Moreover, we documented loss of vitamins A, E, and C into ultrafiltrate.

{diamondsuit} Conclusion: Such low plasma levels of vitamins A, E, and C and simultaneously decreased activity of erythrocyte GSH may be responsible for the increased oxidative stress occurring in children with CKD on PD.

KEY WORDS: Chronic kidney disease in children; antioxidant defense; reduced glutathione (GSH); oxidized glutathione (GSSG); vitamins A, E, C.

Received 12 September 2007; accepted 25 May 2008.






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