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Perit Dial Int 29(1): 81-88
2009
© 2009 International Society for Peritoneal Dialysis
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Clinical

EFFECTS OF INTERLEUKIN-6 T15A SINGLE NUCLEOTIDE POLYMORPHISM ON BASELINE PERITONEAL SOLUTE TRANSPORT RATE IN INCIDENT PERITONEAL DIALYSIS PATIENTS

Young-Hwan Hwang1, Min-Jeong Son2, Jaeseok Yang3, Kiwon Kim4, Wookyung Chung3, Kwon-Wook Joo2, Yonsu Kim2, Curie Ahn2,5,6 and Kook-Hwan Oh2,5,7

Department of Internal Medicine,1 Eulji General Hospital; Department of Internal Medicine,2 Seoul National University Hospital, Seoul; Gachon University of Medicine and Science,3 Incheon; National Cancer Center,4 Gyeonggi-Do; Transplantation Research Institute,5 Cancer Research Institute,6 and Clinical Research Center,7 Seoul National University, Seoul, Korea

Correspondence to: K.H. Oh, Department of Internal Medicine, Seoul National University Hospital, 28 Yongon-Dong, Chongno-Gu, Seoul, 110–744, Republic of Korea. ohchris{at}hanmail.net

{diamondsuit} Objective: To study the genetic effects of various inflammatory cytokines on peritoneal solute transport rate (PSTR) in incident Korean peritoneal dialysis (PD) patients.

{diamondsuit} Design: Case-control association study.

{diamondsuit} Methods: 132 patients with baseline peritoneal equilibration test within 1 – 3 months after starting PD were enrolled. We analyzed the influence of single nucleotide polymorphisms (SNPs) of interleukin-6 (IL-6; -572G/C, T15A), tumor necrosis factor-alpha (TNF-{alpha}; -1031C/T, -863C/A, -308G/A), and IL-10 (-1082A/G, -592A/C) on baseline PSTR. Clinical parameters such as age, gender, presence of diabetes mellitus, comorbidity, C-reactive protein, and residual renal function were also included as covariates.

{diamondsuit} Results: The T15A SNP of IL-6 (rs13306435) was associated with PSTR. Patients with TA genotype (n = 18) had significantly lower D4/P creatinine (0.65 ± 0.087 vs 0.73 ± 0.110, p = 0.0046) and higher D4/D0 glucose (0.39 ± 0.174 vs 0.31 ± 0.119, p = 0.027) than patients with TT genotype (n = 114). The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine (r2 = 0.1294, p < 0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7 ± 14.42 vs 116.8 ± 88.91 pg/minute, p = 0.0358). By multiple logistic regression, TA genotype was negatively associated with a higher PSTR (high or high average; odds ratio 0.18; 95% confidence interval 0.048 – 0.666).

{diamondsuit} Conclusions: In incident Korean PD patients, T15A polymorphism of IL-6 is associated with dialysate IL-6 concentration and baseline PSTR.

KEY WORDS: Interleukin-6; single nucleotide polymorphism.

Received 30 January 2008; accepted 12 May 2008.




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K.-H. Oh, J. Y. Jung, M. O. Yoon, A. Song, H. Lee, H. Ro, Y.-H. Hwang, D. K. Kim, P. Margetts, and C. Ahn
Intra-peritoneal interleukin-6 system is a potent determinant of the baseline peritoneal solute transport in incident peritoneal dialysis patients
Nephrol. Dial. Transplant., January 12, 2010; (2010) gfp670v2.
[Abstract] [Full Text] [PDF]


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