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Perit Dial Int 29(1): 5-15
2009
© 2009 International Society for Peritoneal Dialysis
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IN-DEPTH REVIEW

INTRAPERITONEAL ADMINISTRATION OF DRUGS IN PERITONEAL DIALYSIS PATIENTS: A REVIEW OF COMPATIBILITY AND GUIDANCE FOR CLINICAL USE

Filip de Vin1, Peter Rutherford2 and Dirk Faict1

Baxter R&D Europe,1 Nivelles, Belgium, and Medical Affairs,2 Baxter Healthcare SA, Zurich, Switzerland

Correspondence to: D. Faict, Baxter R&D Europe, Rue du Progrès 7, 1400 Nivelles, Belgium. dirk_faict{at}baxter.com

ABSTRACT

Peritoneal dialysis (PD) is an effective home-based therapy for end-stage renal failure. Intraperitoneal administration of drugs to PD patients is particularly important for the treatment of peritonitis. Clinicians need to know that the administered drug is compatible with both the PD solution and its container. A detailed literature search on drug compatibility and stability was performed and results of all published stability studies are presented for all drugs, PD solutions, and containers studied. These data will aid clinicians managing PD patients and provide a resource to demonstrate which drugs have been shown to be stable in various PD solutions and solution containers. This is important information to assist clinicians in applying effective treatments, in particular, for peritonitis.

KEY WORDS: Solutions; drug; stability; compatibility; intraperitoneal; adsorption; container.

Received 28 March 2008; accepted 12 May 2008.




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