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Perit Dial Int 28(Supplement_3): 144-149 2008
© 2008 International Society for Peritoneal Dialysis
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Part 6: Peritoneal Transport

NEW INSIGHTS INTO THE PHYSIOLOGY OF PERITONEAL FLUID TRANSPORT

Raymond T. Krediet1, Annemieke M. Coester1, Alena Parikova1,a, Watske Smit1,2 and Dirk G. Struijk1,2

1 Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam,2 and Dianet Foundation Amsterdam/Utrecht, Netherlands

Correspondence to: Raymond T. Krediet, Room F4-215, Academic Medical Center, Division of Nephrology, Department of Medicine, PO Box 22700, Amsterdam 1100 DE Netherlands.
C.N.deboer{at}amc.uva.nl

A review is given on the mechanisms of free water transport, the various methodologies for its measurement, its dependency on the osmotic gradient, and the assessment of osmotic conductance in individual patients. The importance of impaired free water transport in long-term ultrafiltration failure is discussed, relative to peritoneal solute transport status. Furthermore, the relationship of free water transport with locally released potassium is considered, together with a potential role of impaired K+ channel function with peritoneal alterations. Finally, the role of impaired osmotic conductance to glucose and its effects on free water transport in long-term patients with ultrafiltration failure is reviewed.

KEY WORDS: Free water transport; small pore transport; osmotic conductance; ultrafiltration failure; potassium release.






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