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Perit Dial Int 28(Supplement_2): 5-10 2008
© 2008 International Society for Peritoneal Dialysis
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INVITED REVIEWS

CHRONIC KIDNEY DISEASE – MINERAL BONE DISORDER

Sharon M. Moe

Indiana University School of Medicine and Roudebush VAMC, Indianapolis, Indiana, U.S.A.

Correspondence to: S.M. Moe, Indiana University School of Medicine, 1001 W. 10th Street, OPW 526, Indianapolis, Indiana 46202 U.S.A. smoe{at}iupui.edu

The definition, evaluation, and classification of the mineral abnormalities and bone disease in chronic kidney disease (CKD) should encompass all three clinical components:

This principle was discussed at a Kidney Disease: Improving Global Outcomes consensus conference, resulting in a recognition of the shortcomings of the current classification and a recommendation for the development of new terminology. The recommendation was that the term "renal osteodystrophy" be used exclusively to define the bone pathology associated with CKD. The many clinical, biochemical, and imaging abnormalities that have heretofore been identified as correlates of renal osteodystrophy should be defined more broadly as a clinical entity or syndrome called "chronic kidney disease – mineral and bone disorder." The hope is that this new terminology will enhance communication and facilitate research worldwide.

KEY WORDS: Mineral bone disorder; renal osteodystrophy; calcium; phosphorus; parathyroid hormone; vascular calcification; bone.







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