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Perit Dial Int 28(1): 67-72 2008
© 2008 International Society for Peritoneal Dialysis
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ORIGINAL ARTICLES

A RANDOMIZED CONTROLLED TRIAL COMPARING MUPIROCIN VERSUS POLYSPORIN TRIPLEa FOR THE PREVENTION OF CATHETER-RELATED INFECTIONS IN PERITONEAL DIALYSIS PATIENTS (THE MP3 STUDY)

Sarbjit V. Jassal, Charmaine E. Lok the MP3 Study Group

Department of Medicine, University of Toronto, and Division of Nephrology, University Health Network, Toronto, Ontario, Canada

Correspondence to: S.V. Jassal, University Health Network, 8NU-857, 200 Elizabeth Street, Toronto, M5G 2C4 Ontario, Canada. vanita.jassal{at}uhn.on.ca

{diamondsuit} Background: Peritonitis remains the most serious complication of peritoneal dialysis (PD). Gram-positive organisms are among the most common causes of PD peritonitis; however, recent trends show increasing rates of gram-negative and fungal infections. Strategies to prevent peritonitis include the use of prophylactic topical mupirocin at the site where the PD catheter exits from the abdominal wall; however, mupirocin does not afford protection against gram-negative or fungal infections. The aim of this study is to determine if the incidence of catheter-related infections (exit-site infection, tunnel infection, or peritonitis) is significantly reduced by the routine application of Polysporin Triple antibiotic ointment (Pfizer Canada, Markham, Ontario, Canada) in comparison to mupirocin ointment.

{diamondsuit} Methods and Design: The Mupirocin Versus Polysporin Triple Study (MP3) is a multicenter, randomized, double-blinded controlled study comparing Polysporin Triple (P3) against the current standard of care. The aim of the study is to recruit 200 patients being treated with or starting on PD and randomize them to receive either mupirocin or P3 at the catheter exit site. Patients will be followed for 18 months or until death or transfer from PD to an alternate treatment modality. The primary outcome will be the time to first catheter-related infection. Catheter-related infections will be strictly defined using current guidelines and categorized into exit-site infections, infective peritonitis, or tunnel infections. The primary analysis will be an intention-to-treat analysis.

{diamondsuit} Discussion: The results of this study will help determine if the use of P3 is superior to mupirocin ointment in the prevention of catheter-related infections and will help guide evidence-based best practices.

KEY WORDS: Double blind, randomized controlled trial; peritonitis; exit site; mupirocin ointment.

Received 17 May 2007; accepted 6 July 2007.






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