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Perit Dial Int 27(Supplement_3): 17- 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical Experience

The Brazilian Multicentric Study on Peritoneal Dialysis (ECMDP): Characterization of the Cohort

N. Fernandes, S.L. Bettoni, R.V. Valenzuela, M.M. Lima, S.W. Pinto, M.C. Riella, R. Pecoits-Filho, J.C. Divino Filho the Brazilian Multicentric Study on Peritoneal Dialysis (ECMDP) Group

Curitiba, Brazil

Objective: The ECMDP was initiated in April 2005 aiming, in the first phase, to collect data monthly and continuously from a representative cohort, allowing for a snapshot of the peritoneal dialysis (PD) reality in the country. In the next phases, the study will aim to improve the quality and knowledge of PD therapy, based on medical evidence generated from clinical trials of excellence. Methods: This was an observational cohort study of PD patients (pts) followed during a mean time of 6.89 months in 111 Brazilian clinics with more than 10 pts. All centers reported data through a central Web-based database. After an initial baseline retrospective data collection, all pts are followed prospectively every month until dropout from the PD program. This preliminary report includes data from pts collected from April 2005 to May 2006. Results: Total number of pts recruited was 3226 (mean age 54±19, 47% males, 61% Caucasians, and 30% blacks), which represents 46% of the total number of PD pts in the country. The more frequent causes of renal failure were diabetes (36%), nephrosclerosis (22%), and glomerulopathies (13%). The most common observed comorbidities were ischemic heart disease (23%), peripheral vascular disease (11%), and malignancy (2%). Mean BMI was 24±5 with 36% of pts having a BMI of <20. 85% of pts reported Karnofsky index >70. CAPD was prescribed to 54% and APD to 46% of the pts in the registry. The estimated overall peritonitis rate was 1 episode/25 pt-months. The gross mortality was 9.2% mainly due to cardiac (57%) and infections (12%) complications. 10% of pts dropped out of PD to receive a renal transplant. Conclusions: This preliminary report of ECMDP displays the main characteristics of Brazilian PD pts in a representative cohort. The low gross mortality results, comorbidities, and peritonitis rates observed in the Brazilian registry are not very different than those reported by other international registries. The initial results of this first Brazilian PD registry provide a unique opportunity to develop future clinical studies addressing specific PD questions in the Brazilian reality and context.






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