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Perit Dial Int 27(Supplement_3): 17- 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical Experience

Comparison Between CAPD and APD Incident Patients in the Brazilian Multicentric Clinical Study on Peritoneal Dialysis (ECMDP)

K. Bastos, S. Ferreira Filho, V. Mendonca Lemos, M. Abdo, M.I. Vannuchi, A. Mocelin, J. Divino-Filho, R. Pecoits-Filho the Brazilian Multicentric Clinical Study on Peritoneal Dialysis (ECMDP)

Curitiba, Brazil

Objective: Although automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD) are distinct forms of renal replacement therapy, there is scarce data comparing the clinical outcome in those therapies. The aim of this study was to compare the baseline biochemical parameters and clinical characteristics, as well as clinical outcome of incident patients enrolled in the ECMDP during the first year.

Methods: This study recruited 1215 CAPD and 880 APD patients starting PD. The most common ESRD etiology was diabetes mellitus (DM) 36% in CAPD and 41% in APD, glomerulopathy 10% in CAPD and 12% in APD, and unknown etiology 11% in CAPD and 14% in APD. The mean follow-up time was 6.7 months on CAPD and 6.3 months on APD.

Results: There were no statistical differences between groups regarding age, but there were more females (56%) in CAPD than in APD (47%) (p<0.001). Hematocrit, Hb, glucose, phosphate, calcium, potassium, TGP, creatinine, and urea levels at the baseline were similar in both therapies. The comorbid state (i.e., malignancies, left ventricular hypertrophy, and peripheral vascular disease) had similar frequency in both treatment. Ischemic heart disease and DM were observed more frequently in APD than CAPD patients (p<0.001). The patients treated with APD had better survival than patients treated with CAPD (log rank test 4.8, p=0.02), which was still significant after adjusting for confounding factors.

Conclusions: These observational, cross-sectional results suggest that APD therapy may have a positive influence on the outcome of patients with diabetes and ischemic heart disease, when compared to CAPD.






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