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Perit Dial Int 27(Supplement_3): 17- 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical Experience

Cross-Sectional Comparison of Prevalent Patients Treated with CAPD and APD in the Brazilian Multicentric Clinical Study on Peritoneal Dialysis (ECMDP)

H.V. Cassi, N. Leite Machado, J.A. Ribeiro, G. Martins, O. Mourao, J. Divino Filho, R. Pecoits-Filho, M.C. Riella the Brazilian Multicentric Study on Peritoneal Dialysis (ECMDP) Group

Curitiba, Brazil

Objective: The ECMDP was initiated in April 2005 and has so far recruited 3226 ESRD undergoing peritoneal dialysis (PD) in 111 Brazilian centers with more than 10 patients (pts) on PD. The aim of this study was to report the preliminary cross-sectional analysis of data related to prevalent continuous ambulatory PD (CAPD) and automated PD (APD) pts. Methods: There were 1713 pts on CAPD (56% female) and 1513 on APD (51% female). Diabetes mellitus was the main cause of ESRD in both groups (31% and 36% respectively) and there was not significant difference in age. The prevalence of comorbidity is described in the Table below. Results: Regarding the biochemical parameters the CAPD pts had significantly higher values of urea (105 vs 102), potassium (4.6 vs 4.2), calcium (8.9 vs 8.2), and phosphate (5.2 vs 5.1), whereas the APD pts had significantly higher values of creatinine (7.6 vs 7.2), hemoglobin (11.3 vs 10.8), and hematocrit (33.7 vs 33.0). There was no statistical significant difference in peritonitis rate between the groups (CAPD: 1 episode every 25 pt/months; APD: 1 episode every 23 pt/months) and 378 and 477 cases of exit-site infections were reported in APD and CAPD respectively. The Karnofsky score was >70 for 86% of the CAPD pts and 85% of the APD pts. There is a trend for shorter pt survival in CAPD when compared to APD during the 14 months of follow-up (2.72, p=0.09; log rank test).

APD (%) CAPD (%) p Values DM 36 31 0.008 IHD 22 16 0.002 PVD 20 17 0.04 LVH 35 39 0.03 Malignancy 2 2 NS

Conclusions: These results provide an overview of the PD therapy status in Brazil through a considerable part (46%) of the PD population, pinpointing some differences between CAPD and APD that need further exploration of the gathered data. The design of prospective studies to confirm or not these cross-sectional observations is required.






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