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Risk Factor Associated to Cardiac Hypertrophy on Peritoneal Dialysis. Rio de la Plata Study

Estudio Rio de la Plata, Buenos Aires, Argentina

Objective: To identify and to analyze the risk factor by cardiac hypertrophy in patients on peritoneal dialysis (PD).

Methods: Patients aged >18 on PD >3 months were enrolled. Patients with cancer, liver chronic disease, IES, rheumatic or congenital heart disease were excluded. 124 PD patients by Rio de la Plata Registry were analyzed. Left ventricular mass index (LVMi), RGF rate, CRP, hemoglobin, albumin, and BP were determined. LVH (g/m²) was defined as LVMi >47 women and >50 men. Inflammation as denoted by CRP>2.6 mg/L.

Results: Statistical Analysis: STATA 7.0. t-Test, Mann–Whitney or Kruskal–Wallis test was used. 92% had LVI; 69% had CRP>2.6. Age: 50±14.3 years; dialysis time: 24 (10–48) months; smoking history 15%; diabetes 26%; coronary artery disease 18.6%; atherosclerotic disease 22%. On erythropoietin 77%; history BP 83%; systolic BP: 125±17; diastolic BP: 80±12.8; LVMi: 92 (70–143); BMI: 26 (23–30); Hb: 11±2.46; with RRF 61%; RGF rate: 2.1 (0–3.7). LVMi was positively correlated with Hb<9 (p>0.02) and previous HD: odds ratio 3.24 (p>0.005), CI (1.4–7.6). NS difference LVMi groups RRF, CRP<2.6 and no RRF, CRP>2.6. All comparisons were adjusted by BP, sex, age, previous HD.

Conclusions: LVMi was correlated with Hb<9 and previous HD. NS difference LVMi groups with RRF, CRP<2.6 and no RRF, CRP>2.6.

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