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Perit Dial Int 27(Supplement_2): 72-75
2007
© 2007 International Society for Peritoneal Dialysis
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Inflammation and Fibrosis

IN VITRO STUDY OF PERITONEAL FIBROSIS

Kuan-Yu Hung, Kuan-Dun Wu and Tun-Jun Tsai

Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

Correspondence to: T.J. Tsai, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan. paul{at}ha.mc.ntu.edu.tw

Peritoneal fibrosis (PF) is an important issue in peritoneal dialysis (PD) because it remains one of the leading causes of patient drop-out from PD. In this review, we focus on in vitro approaches to the pathogenesis and therapeutic potential of PF and on associated clinical implications. Representative Asian studies, initiated since mid-1990s, that have investigated matrix accumulation in peritoneal tissue possibly leading to PF in the PD population will be highlighted as examples to learn how to apply this research tool. As compared with data from well-designed clinical trials, observations from in vitro models may be far from becoming solid evidence; however, they do cast new light on options for investigations into therapeutic pharmaceuticals.

KEY WORDS: In vitro study; peritoneal fibrosis; mesothelial cell; fibroblast; cytokine; tamoxifen.




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K.-Y. Hung, J.-W. Huang, C.-K. Chiang, and T.-J. Tsai
Preservation of peritoneal morphology and function by pentoxifylline in a rat model of peritoneal dialysis: molecular studies
Nephrol. Dial. Transplant., December 1, 2008; 23(12): 3831 - 3840.
[Abstract] [Full Text] [PDF]


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