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Perit Dial Int 27(Supplement_2): 293-297
2007
© 2007 International Society for Peritoneal Dialysis
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Part 9: Miscellaneous Complications and Pathophysiologic Mechanisms

SYMPATHETIC HYPERACTIVITY—A HIDDEN ENEMY IN CHRONIC KIDNEY DISEASE PATIENTS

Peter J. Blankestijn

Department of Nephrology, University Medical Center, Utrecht, Netherlands

Correspondence to: P.J. Blankestijn, Department of Nephrology, Room F03.226, University Medical Center, PO Box 85500, Utrecht 3508 GA Netherlands. P.J.Blankestijn{at}umcutrecht.nl

Chronic kidney disease is often characterized by the presence of sympathetic hyperactivity. The aim of this brief review is to summarize available knowledge on the pathogenesis of sympathetic hyperactivity and to discuss its clinical relevance, the consequences of this knowledge for the choice of treatment, and the yet unresolved issues.

KEY WORDS: Chronic kidney disease; renal hypertension; sympathetic activity; angiotensin II.






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