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Perit Dial Int 27(Supplement_2): 205-209
2007
© 2007 International Society for Peritoneal Dialysis
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Part 6: Cardiovascular Complications in PD

RISK FACTORS FOR CARDIOVASCULAR DISEASE IN PATIENTS UNDERGOING PERITONEAL DIALYSIS

Elvia García–López, Juan J. Carrero, Mohamed E. Suliman, Bengt Lindholm and Peter Stenvinkel

Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

Correspondence to: P. Stenvinkel, Department of Renal Medicine, K56, Karolinska University Hospital at Huddinge, Stockholm 14186 Sweden. peter.stenvinkel{at}ki.se

Patients on peritoneal dialysis (PD) are at high cardiovascular risk. Although some risk factors are unmodifiable (for example, age, sex, genetics), others are exacerbated in the unfriendly uremic milieu (inflammation, oxidative stress, mineral disturbances) or contribute per se to kidney disease and cardiovascular progression (diabetes mellitus, hypertension). Moreover, several factors associated with PD therapy may both increase (by altered lipid profile, hyperinsulinemia, and formation of advanced glycation end-products) and decrease (by better blood pressure control and anemia management) cardiovascular risk. The present review discusses recent findings and therapy trends in cardiovascular research on the PD population, with emphasis on the roles of inflammation, insulin resistance, homocysteinemia, dyslipidemia, vascular calcification, and genetics/epigenetics.

KEY WORDS: Cardiovascular disease; inflammation; vascular calcification; homocysteine.




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