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Part 6: Cardiovascular Complications in PD |
Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Correspondence to: P. Stenvinkel, Department of Renal Medicine, K56, Karolinska University Hospital at Huddinge, Stockholm 14186 Sweden. peter.stenvinkel{at}ki.se
Patients on peritoneal dialysis (PD) are at high cardiovascular risk.
Although some risk factors are unmodifiable (for example, age, sex, genetics),
others are exacerbated in the unfriendly uremic milieu (inflammation,
oxidative stress, mineral disturbances) or contribute per se to
kidney disease and cardiovascular progression (diabetes mellitus,
hypertension). Moreover, several factors associated with PD therapy may both
increase (by altered lipid profile, hyperinsulinemia, and formation of
advanced glycation end-products) and decrease (by better blood pressure
control and anemia management) cardiovascular risk. The present review
discusses recent findings and therapy trends in cardiovascular research on the
PD population, with emphasis on the roles of inflammation, insulin resistance,
homocysteinemia, dyslipidemia, vascular calcification, and
genetics/epigenetics.
KEY WORDS: Cardiovascular disease; inflammation; vascular calcification; homocysteine.
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