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Perit Dial Int 27(6): 687-690 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical

ULTRAFILTRATION AND ABSORPTION IN EVALUATING AQUAPORIN FUNCTION FROM PERITONEAL TRANSPORT OF SODIUM

Jacek Waniewski1,2, Malgorzata Debowska1 and Bengt Lindholm2

Institute of Biocybernetics and Biomedical Engineering,1 Warsaw, Poland; Divisions of Baxter Novum and Renal Medicine,2 Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

Correspondence to: J. Waniewski, Institute of Biocybernetics and Biomedical Engineering, Trojdena 4, PL 02 109 Warsaw, Poland. jacekwan{at}ibib.waw.pl

{diamondsuit} Background: Evaluation of free water transport is a tool for assessing aquaporin function in peritoneal dialysis patients. The dialysate "sodium dip" and estimation of sieving coefficient for sodium may be used for quantification of the free water fraction in ultrafiltration flow from blood to the peritoneal cavity.

{diamondsuit} Method: The mini peritoneal equilibration test (mini-PET) [La Milia et al., Nephrol Dial Transplant 2002; 17(Suppl 3):17–18] is a simple method for evaluating free water transport using sodium as a marker. We compared the evaluation of free water transport using the mini-PET against detailed data on fluid and sodium transport from clinical dwell studies using a macromolecular volume marker to estimate fluid absorption and ultrafiltration rates, and the modified Babb–Randerson–Farrell model to assess the sodium transport components.

{diamondsuit} Results and Conclusion: According to our results, the mini-PET may result in underestimation of fluid transport by about 20% because it neglects the impact of peritoneal fluid and solute absorption and sodium diffusion during the peritoneal dwell time. Nevertheless, estimation of the free water fraction in the mini-PET yields values (about 0.4) similar to the more detailed analysis.

KEY WORDS: Peritoneal transport; sieving coefficient; mathematical modeling; free water fraction.

Received 27 November 2006; accepted 6 May 2007.






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