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Perit Dial Int 27(6): 663-668 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical

SERUM BNP CONCENTRATION AND LEFT VENTRICULAR MASS IN CAPD AND AUTOMATED PERITONEAL DIALYSIS PATIENTS

Nüket Bavbek1, Hatice Akay2, Mustafa Altay2, Ebru Uz1, Faruk Turgut1, Mehtap E. Uyar3, Aydyn Karanfil4, Yusuf Selcoki4, Ali Akcay1 and Murat Duranay2

Department of Nephrology,1 Fatih University Medical School; Department of Nephrology,2 Ankara Education and Research Hospital; Department of Internal Medicine3 and Department of Cardiology,4 Fatih University Medical School, Ankara, Turkey

Correspondence to: N. Bavbek, Harbiye Mah, Nigde Sokak, 46/2 Dikmen, Ankara, Turkey. ntbavbek{at}yahoo.com

{diamondsuit} Objective: To compare ultrafiltration under continuous ambulatory peritoneal dialysis (CAPD) and automated PD (APD), disclosing potential effects on serum B-type natriuretic peptide (BNP) levels and echocardiographic findings.

{diamondsuit} Patients and Methods: This cross-sectional clinical study included 32 patients on CAPD and 30 patients on APD without clinical evidence of heart failure or hemodynamically significant valvular heart disease. Peritoneal equilibration tests, BNP levels, and echocardiographic measurements were performed in each subject. BNP measurements were also performed in 24 healthy control subjects.

{diamondsuit} Results: Patients on APD had lower ultrafiltration and higher values of BNP and left ventricular mass index (LVMI) compared with patients on CAPD (respectively: 775 ± 160 vs 850 ± 265 mL, p = 0.01; 253.23 ± 81.64 vs 109.42 ± 25.63 pg/mL, p = 0.001; 185.12 ± 63.50 vs 129.30 ± 40.95 g/m2, p = 0.001). This occurred despite higher mean dialysate glucose concentrations and far more extensive use of icodextrin in the APD group.

{diamondsuit} Conclusion: Treatment with APD is associated with higher plasma BNP levels and LVMI compared to CAPD. This may be the result of chronic fluid retention caused by lower ultrafiltration in APD patients.

KEY WORDS: CAPD; APD; ultrafiltration; B-type natriuretic peptide (BNP); left ventricular mass index.

Received 2 March 2007; accepted 24 May 2007.






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