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Perit Dial Int 27(5): 575-579 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical Sciences

EFFECTS OF PERITONEAL RESTING ON PERITONEAL FLUID TRANSPORT KINETICS

Xing-wei Zhe, Xin-kui Tian, Lei Cheng and Tao Wang

Division of Nephrology, Third Hospital, Peking University, Beijing, China

Correspondence to: T. Wang, Division of Nephrology, Third Hospital, Peking University, 49 North Garden Road, Haidian District, Beijing 100083 China. wangt{at}bjmu.edu.cn

{diamondsuit} Background: Peritoneal resting has been used to restore peritoneal ultrafiltration capacity in peritoneal dialysis patients. Therefore, in the present study, we made a detailed investigation on the effects of peritoneal resting on peritoneal fluid transport characteristics in patients on continuous ambulatory peritoneal dialysis (CAPD).

{diamondsuit} Methods: A temporary transfer to daytime ambulatory peritoneal dialysis with a nocturnal "empty belly" was applied to let the peritoneal membrane rest overnight in patients with poor ultrafiltration capacity. All included patients were asked to record appropriately their dialysis exchanges for the assessment of peritoneal fluid transport characteristics, which were evaluated before and after peritoneal resting.

{diamondsuit} Results: Seven CAPD patients were included in the present study. There was a significant improvement in peritoneal ultrafiltration capacity as assessed by ultrafiltration volume per gram of glucose load. Patients' daily glucose exposure and dialysate-to-plasma ratio of creatinine were significantly decreased after peritoneal resting. The peritoneal fluid absorption rate was also significantly decreased after peritoneal resting: 1.011 ± 0.4484 versus 0.625 ± 0.3833 mL/minute.

{diamondsuit} Conclusion: The present study suggests that peritoneal resting can improve CAPD patients' ultrafiltration capacity and decrease the use of hypertonic dialysis solution. The improved ultrafiltration capacity by peritoneal resting was due to decreased membrane solute transport rate and decreased peritoneal fluid absorption rate.

KEY WORDS: Fluid kinetics; peritoneal resting.

Received 16 August 2006; accepted 8 May 2007.






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