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Perit Dial Int 27(4): 456-460 2007
© 2007 International Society for Peritoneal Dialysis
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SHORT REPORTS

Effects of Sulodexide on Hemostatic Factors, Lipid Profile, and Inflammation in Chronic Peritoneal Dialysis Patients

Soon Bae Kim1,*, Su Hee Kim2, Moo Song Lee3, Jai Won Chang1, Sang Koo Lee1 and Jung Sik Park1

1 Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul;2 Division of Nephrology, Department of Internal Medicine, GangNeung Asan Hospital, University of Ulsan College of Medicine, GangNeung; 3 Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea

* e-mail: sbkim{at}amc.seoul.kr

Sulodexide, a standardized extractive glycosaminoglycan containing 80% "fast moving" heparin and 20% dermatan sulfate, decreased plasma D-dimer, a marker of intravascular coagulation, and fibrinogen levels in chronic peritoneal dialysis patients. Blood levels of von Willebrand factor, lipid, and high-sensitivity C-reactive protein were not significantly changed. No bleeding episodes were reported. These results suggest that sulodexide was effective in partially reversing the thrombogenic coagulation profile without increasing the risk of bleeding.

KEY WORDS: Sulodexide; hemostatic factors; lipid; inflammation.






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