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Perit Dial Int 27(4): 375-390
2007
© 2007 International Society for Peritoneal Dialysis
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IN-DEPTH REVIEW

PERITONEAL PROTEOGLYCANS: MUCH MORE THAN GROUND SUBSTANCE

Susan Yung and Tak Mao Chan

Department of Medicine, University of Hong Kong, Hong Kong

Correspondence to: S. Yung, Department of Medicine, Room 302, New Clinical Building, Queen Mary Hospital, Pokfulam Road, Hong Kong.
ssyyung{at}hkucc.hku.hk

Recent advances in the field of glycobiology have exposed a multitude of biological processes that are controlled or influenced by proteoglycans, in both physiological and pathological conditions ranging from early embryonic development, inflammation, and fibrosis to tumor invasion and metastasis. The first part of this article reviews the biosynthesis of proteoglycans and their multifunctional roles in health and disease; the second part of this review focuses on their putative roles in peritoneal homeostasis and peritoneal inflammation and fibrosis in the context of chronic peritoneal dialysis and peritonitis.

KEY WORDS: Proteoglycans; glycosaminoglycans; perlecan; decorin; biglycan; syndecan; peritoneal inflammation; peritoneal fibrosis.

Received 25 March 2007; accepted 18 April 2007.




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