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Perit Dial Int 27(3): 283-287 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical

ANTI-INFLAMMATORY EFFECTS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITORS (STATINS) IN PERITONEAL DIALYSIS PATIENTS

Sanjeev Kumar, Martin Raftery, Magdi Yaqoob and Stanley L.-S. Fan

Nephrology and Transplantation, Barts and The London NHS Trust, London, United Kingdom

Correspondence to: S.L.S. Fan, Department of Renal Medicine and Transplantation, Barts and The London Hospital NHS Trust, Whitechapel, London E1 1BB, United Kingdom. s.fan{at}qmul.ac.uk

{diamondsuit} Objective: Elevated C-reactive protein (CRP) level is an independent predictor of all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients. Statins have been demonstrated to have anti-inflammatory properties by virtue of their CRP lowering effects in hemodialysis patients. However, whether statins have an anti-inflammatory effect in PD patients is unknown.

{diamondsuit} Design: All prevalent PD patients at our center were reviewed. Eligible (257) patients were categorized into 2 groups: those on statin therapy (n = 137) and those not on statins (n = 120). Data were abstracted for hemoglobin, albumin, phosphates, cholesterol, CRP, Kt/V, and erythropoietin dose, along with relevant clinical data.

{diamondsuit} Results: The two groups had similar concentrations of hemoglobin, albumin, and phosphates. They were also matched for dialysis adequacy and duration of dialysis but the statin group patients were older (57 ± 13 vs 52 ± 17 years, p = 0.01). Serum cholesterol was lower in the statin group (4.74 ± 1.05 vs 5.02 ± 1.17 mmol/L, p < 0.05). Single-point (14 ± 13 vs 19 ± 18 mg/L, p < 0.02) and serially measured CRP (9 ± 7.4 vs 12 ± 10 mg/L, p < 0.02) levels were significantly lower in the statin group despite increased comorbidity (0.84 vs 0.54, p < 0.02) and greater incidence of diabetes mellitus (52% vs 25%, p < 0.01).

{diamondsuit} Conclusion: Statin therapy is associated with low single-point and serially measured CRP levels in PD patients, thereby suggesting that their anti-inflammatory properties persist in PD. These data have implications for considering statin therapy in PD patients as an anti-inflammatory agent in addition to a cholesterol lowering drug.

KEY WORDS: KEY WORDS:; Statins; anti-inflammatory; CRP.

Received 9 September 2005; accepted 29 December 2006.




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