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Perit Dial Int 27(1): 74-78 2007
© 2007 International Society for Peritoneal Dialysis
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Clinical

SEN VIRUS INFECTION IN PATIENTS ON PERITONEAL DIALYSIS

Bang-Gee Hsu1,2,4, Li-Yu Wang5, Chi-Tan Hu2,3, Chih-Hsien Wang1, Te-Chao Fang1 and Hans Hsienhong Lin2,3,4

1 Department of Nephrology,2 Research Center for Hepatology, and3 Department of Gastroenterology, Buddhist Tzu Chi General Hospital; 4 College of Medicine and Graduate Institute of Aboriginal Health,5 Buddhist Tzu Chi University, Hualien, Taiwan

Correspondence to: H.H. Lin, Department of Gastroenterology, Buddhist Tzu Chi General Hospital, 707, Section 3, Tsung-Yang Road, Hualien, Taiwan.
yoyo{at}tzuchi.com.tw

{diamondsuit} Background: Many reports have demonstrated SEN virus (SEN-V) infection rates in hemodialysis patients, but the SEN-V infection rate in peritoneal dialysis (PD) patients has never been reported. In this study, we determined the prevalence rate of SEN-V viremia in a PD population.

{diamondsuit} Methods: Serum samples from 47 PD patients and a control group of 43 subjects from the general population at their health examination were assayed for SEN-V-D and -H viremia using polymerase chain reaction.

{diamondsuit} Results: The proportions of female gender (p = 0.001), previous transfusion (p < 0.0001), and higher mean serum AST level (p = 0.012) were significantly higher in PD patients. The prevalence rates of SEN-V-D and/or -H viremia were not significantly different between PD patients and controls (27.7% vs 32.6%). SEN-V-D(+) patients had lower mean duration of PD than SEN-V(-) patients. Mean ALT level was significantly lower in SEN-V-H(+) than in SEN-V(-) patients (12.8 ± 5.8 vs 19.6 ± 12.1 (IU/L), p = 0.025). None of the SEN-V-infected PD patients had overt clinical or biochemical signs of liver disease. There were no statistically significant differences in prevalence of SEN-V-D and/or -H viremia between automated PD (APD) patients and continuous ambulatory PD (CAPD) patients.

{diamondsuit} Conclusions: These results indicate that the SEN-V infection rate is not different between healthy individuals and PD patients. Infection with SEN-V is not associated with evident liver disease in PD patients and SEN-V infection rate is not different between APD patients and CAPD patients.

KEY WORDS: SEN virus; prevalence.

Received 21 January 2006; accepted 5 May 2006.






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