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FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY DETECTS THE INFLAMMATORY PHASE OF SCLEROSING PERITONITIS

Renal Unit¹ and Department of Nuclear Medicine,² Charing Cross Hospital, London, United Kingdom

Correspondence to: R. Tarzi, Department of Renal Medicine, Hammersmith Hospital, Du Cane Road, London, W12 0NN, United Kingdom.
r.tarzi{at}imperial.ac.uk

• Objective: We studied the effectiveness of ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting inflammation in known or suspected cases of sclerosing peritonitis in patients on peritoneal dialysis (PD).
  
• Design: We undertook FDG-PET scanning in PD patients presenting with symptoms or signs suggestive of sclerosing peritonitis (SP), and in patients on long-term PD with no symptoms of SP.
  
• Setting: The study was performed in a PD unit in a tertiary-care hospital.
  
• Patients and Methods: Three patients with known or strongly suspected SP underwent FDG-PET scans, 1 within 3 months of presentation with symptoms and 2 who were scanned more than 9 months after presentation. One patient was scanned at an early and a late time point. Five patients who had been on PD for more than 5 years and who were asymptomatic also underwent FDG-PET scanning. Scans were interpreted by a specialist in nuclear medicine.
  
• Results: The scan performed in the early stages of SP showed increased peritoneal uptake. However, three scans taken more than 9 months after presentation with suspected SP showed mild peritoneal abnormalities only. One of 5 asymptomatic long-term PD patients showed increased peritoneal uptake associated with loss of ultrafiltration and high transporter status.
  
• Conclusions: FDG-PET scanning may be a useful adjunct in the diagnosis of the acute phase of SP. More study is needed to define its role in the diagnosis of SP in asymptomatic PD patients.
  

KEY WORDS: Sclerosing peritonitis; encapsulating sclerosing peritonitis; FDG-PET scan; complications of peritoneal dialysis.

Received 30 March 2005; accepted 11 July 2005.

Copyright © 2006 by Multimed Inc.