HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Cheng, L.-T. Articles by Wang, T. Search for Related Content PubMed PubMed Citation Articles by Cheng, L.-T. Articles by Wang, T.

CHANGES IN TOTAL SODIUM INTAKE DO NOT LEAD TO PROPORTIONATE CHANGES IN TOTAL SODIUM REMOVAL IN CAPD PATIENTS

Institute of Nephrology, First Hospital, Peking University, Beijing, China

Correspondence to: T. Wang, Institute of Nephrology, First Hospital, Peking University, 8 Xishiku Street, Beijing 100034, P.R. China.
wangt{at}bjmu.edu.cn

• Background: Dietary salt and fluid restriction is important in controlling fluid balance in patients on continuous ambulatory peritoneal dialysis (CAPD). However, it is often difficult to monitor patients' dietary total sodium intake (TSI). Usually, total sodium removal (TSR), the sum of urinary sodium removal (USR) and dialysate sodium removal (DSR), is suggested to represent TSI. In the present study, we investigated the reliability of using TSR as a surrogate to TSI in CAPD patients.
  
• Methods: 40 clinically stable CAPD patients were closely followed for 3 months. Their TSI, USR, DSR, and fluid status were measured twice: at baseline and at the end of this study respectively. Fluid status was evaluated by bioimpedance analysis. Patients with increased sodium intake (group ISI) or decreased sodium intake (group DSI) (both >0.5 g/day or >21.74 mmol/day elemental sodium) were included in this study.
  
• Results: There were 15 patients in group ISI and 9 patients in group DSI. During the follow-up, although TSI increased in group ISI and decreased in group DSI (p < 0.05), there were no significant changes in USR, DSR, or TSR in either group. No relationship was found between TSI and TSR. Changes in weight, blood pressure, urine volume, ultrafiltration, and small solute removal (Kt/V and creatinine clearance) were not statistically significant between the two groups. Fluid status deteriorated in group ISI and improved in group DSI (p < 0.05).
  
• Conclusions: Our study suggests that changes in total sodium intake do not lead to proportionate changes in total sodium removal in CAPD patients. Therefore, TSR (the sum of USR and DSR) should be used cautiously to monitor TSI in this patient population.
  

KEY WORDS: Fluid status; sodium autoregulation; dietary salt intake.

Received 16 June 2004; accepted 20 July 2005.

Copyright © 2006 by Multimed Inc.