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FLUID STATUS AND ITS MANAGEMENT IN JAPANESE PERITONEAL DIALYSIS PATIENTS

Research Division of Dialysis and Chronic Kidney Disease, Tohoku University, Graduate School of Medicine, Sendai, Japan

Correspondence to: M. Nakayama, Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.
mnakayama{at}mail.tains.tohoku.ac.jp

This article reviews published studies related to fluid status of Japanese peritoneal dialysis (PD) patients and its impact on technique and patient survival. In addition, some specifics related to clinical background that potentially influence fluid status are described. According to a multicenter survey conducted in Japan, nearly 25% of Japanese PD patients are overhydrated. Available data indicate that a high salt diet may conceivably play an important role in the pathogenesis of fluid overload in Japanese PD patients, and it in turn negatively impacts patient prognosis. Because of the generally adopted policy among Japanese PD experts to avoid regular use of 3.86% glucose solution, icodextrin solution is now used in more than one third of all patients. Other means of managing fluid overload, such as drug therapy, combination (complementary) therapy with hemodialysis, and low sodium PD solution, are also explored and summarized in this article.

KEY WORDS: Fluid status; hypervolemia; overhydration; blood pressure; salt intake; tranexamic acid; combination therapy; low sodium solution; Japan.

Received 7 June 2005; accepted 8 February 2006.

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