OBJECTIVE: A pilot study to compare the use of a combination dialysate (7.5% icodextrin/1.36% glucose) versus icodextrin 7.5% alone for the long dwell in patients on peritoneal dialysis (PD). DESIGN: A 4-week, prospective, randomized crossover study. SETTING: A large regional renal unit providing treatment for a population of 1.7 million. PATIENTS: Five patients on continuous ambulatory PD (CAPD) and 3 patients on automated PD. MAIN OUTCOME MEASUREMENTS: Long-dwell and 24-hour ultrafiltration volumes, body weight, 24-hour ambulatory blood pressure, and antihypertensive/diuretic tablet count. RESULTS: The use of the combination dialysate resulted in an increase in the median (interquartile range) long-dwell ultrafiltration, from 750 (650-828) mL to 1000 (889-1100) mL (p < 0.001), and 24-hour ultrafiltration, from 739 (400-1623) mL to 956 (700-1750) mL (p < 0.001). Weight, blood pressure, and tablet count remained unchanged. CONCLUSIONS: The use of the novel combination dialysate resulted in a 33% increase in long-dwell ultrafiltration and a 29% increase in 24-hour ultrafiltration.

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