OBJECTIVE: To evaluate the possible associations between peritoneal transport rate (PTR), fluid removal, inflammation, and nutritional status in patients treated with peritoneal dialysis (PD) for more than 6 months, and the impact of these factors on subsequent patient survival. DESIGN AND PATIENTS: A prospective study of 82 PD patients (48 males) that had been treated with PD more than 6 months. Based on the dialysate-to-plasma creatinine ratio at 4 hours of dwell (D/P Cr; mean +/- 1 SD), the patients were classified as having a high (H), high-average (HA), low-average (LA), or low (L) PTR. SETTING: Single PD unit in a university hospital. MAIN OUTCOME MEASURES: The PTR, evaluation of adequacy of dialysis and nutritional status, and biochemical analyses were assessed at 10.8 +/- 2.8 months after the start of PD. RESULTS: Compared to L and LA (L/LA) transporters, H and HA (H/HA) transporters had increased dialysate protein loss, glucose absorption from dialysate, and peritoneal creatinine clearance (CCr), and decreased night ultrafiltration volume and total Kt/V urea. However, nutritional variables, 24-hour total fluid removal (TFR), total CCr, and residual renal function were not significantly different between the two groups. The 24-hour TFR correlated significantly with D/P Cr (rho = -0.25), mean arterial pressure (rho = -0.23), serum albumin (rho = 0.25), normalized protein equivalent of total nitrogen appearance (rho = 0.34), lean body mass (LBM) calculated from creatinine kinetics (rho = 0.41), total Kt/N urea (rho = 0.42), and total CCr (rho = 0.30). The group with serum C-reactive protein (sCRP) > or = 10 mg/L had a higher proportion of patients with reduced (< 1,000 mL) TFR compared to the group with sCRP < 10 mg/L (38% vs 16%, p = 0.04). Two-year patient survival rates from the time of the assessment were not different between the different transport groups (78% vs 73% for H/HA and L/LA, p = 0.99). Upon Cox proportional hazards multivariate analysis, age and high sCRP were independent predictors of mortality. CONCLUSIONS: This study shows that, in a selected group of prevalent PD patients assessed after more than 6 months of PD therapy, (1) inflammation was an independent predictor for mortality; (2) reduced TFR was associated with impaired nutritional status, decreased small solute clearance, and inflammation; and (3) peritoneal transport status was not significantly associated with nutritional status and was not associated with subsequent patient survival. These results indicate that a high peritoneal solute transport rate, as such, should not be regarded as a relative contraindication for PD. Instead, the results suggest that more attention should be given to inflammation and inadequate fluid removal as predictors of mortality in PD patients.

This article has been cited by other articles:

				K. J. Wiggins, S. P. McDonald, F. G. Brown, J. B. Rosman, and D. W. Johnson High membrane transport status on peritoneal dialysis is not associated with reduced survival following transfer to haemodialysis Nephrol. Dial. Transplant., October 1, 2007; 22(10): 3005 - 3012. [Abstract] [Full Text] [PDF]

				M.-J. F. Reyes, M.-A. Bajo, C. Hevia, G. del Peso, S. Ros, A. G. de Miguel, A. Cirugeda, M.-J. Castro, J. A. Sanchez-Tomero, and R. Selgas Inherent high peritoneal transport and ultrafiltration deficiency: their mid-term clinical relevance Nephrol. Dial. Transplant., January 1, 2007; 22(1): 218 - 223. [Abstract] [Full Text] [PDF]

				W. Van Biesen, A. Van Der Tol, N. Veys, C. Dequidt, D. Vijt, N. Lameire, and R. Vanholder The Personal Dialysis Capacity Test Is Superior to the Peritoneal Equilibration Test to Discriminate Inflammation as the Cause of Fast Transport Status in Peritoneal Dialysis Patients Clin. J. Am. Soc. Nephrol., March 1, 2006; 1(2): 269 - 274. [Abstract] [Full Text] [PDF]

				M. Rumpsfeld, S. P. McDonald, and D. W. Johnson Higher Peritoneal Transport Status Is Associated with Higher Mortality and Technique Failure in the Australian and New Zealand Peritoneal Dialysis Patient Populations J. Am. Soc. Nephrol., January 1, 2006; 17(1): 271 - 278. [Abstract] [Full Text] [PDF]

				F. Finkelstein, H. Healy, A. Abu-Alfa, S. Ahmad, F. Brown, T. Gehr, K. Nash, M. Sorkin, S. Mujais, and on behalf of the Icodextrin High Transporter Trial Superiority of Icodextrin Compared with 4.25% Dextrose for Peritoneal Ultrafiltration J. Am. Soc. Nephrol., February 1, 2005; 16(2): 546 - 554. [Abstract] [Full Text] [PDF]

Copyright © 2003 by Multimed Inc.