PDI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Perit Dial Int 22(3): 350-356 2002
© 2002 International Society for Peritoneal Dialysis
This Article
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zimmeck, T
Right arrow Articles by Pischetsrieder, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zimmeck, T
Right arrow Articles by Pischetsrieder, M
Peritoneal Dialysis International, Vol 22, Issue 3, 350-356
Copyright © 2002 by International Society for Peritoneal Dialysis

Articles

How to reduce 3-deoxyglucosone and acetaldehyde in peritoneal dialysis fluids

T Zimmeck, A Tauer, M Fuenfrocken, and M Pischetsrieder

Fresenius Medical Care Deutschland GmbH, St Wendel, Germany.

OBJECTIVE: 3-Deoxyglucosone (3-DG) and acetaldehyde were found to be the major reactive carbonyl compounds in conventional heat-sterilized peritoneal dialysis fluids (PDFs). The aim of this study was to identify factors in the production of PDFs promoting or inhibiting the formation of acetaldehyde and 3-DG. DESIGN: Single-chamber bag PDFs with different buffer systems and pH values were analyzed for acetaldehyde. 3-Deoxyglucosone was determined in double-chamber bag PDFs with different pH values, in commercially available samples, and in double-chamber products stored under defined conditions. RESULTS: Acetaldehyde was found in the presence of lactate and malate, whereas in 2-hydroxybutanoate-buffered solution propionaldehyde was detected instead. Between pH 5.0 and 6.0 the acetaldehyde content in lactate-buffered solutions increased strongly.The concentration of 3-DG in the chamber containing glucose In double-chamber bags increased between pH 3.0 and 5.0 by a factor of 6. 3-Deoxyglucosone concentrations in commercially available products vary greatly, reflecting the different pH values of these products. A time- and temperature-dependent reaction leads to a reduction in 3-DG and an increase in 5-hydroxymethyl-furan-2-carbaldehyde during storage. CONCLUSION: Acetaldehyde is produced by a reaction that requires both lactate and glucose. Thus, its formation can be prevented by a separation of the reaction partners, glucose and lactate, in a double-chamber bag. In double-chamber bags, pH greatly influences the formation of 3-DG. Minimal formation is observed in the region of pH 3.0. This finding should be taken into account for the development of new double-chamber bag PDFs.




This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
C. P. Schmitt, D. von Heyl, S. Rieger, K. Arbeiter, K. E. Bonzel, M. Fischbach, J. Misselwitz, A.-K. Pieper, F. Schaefer, and for the Mid European Pediatric Peritoneal Dialysis
Reduced systemic advanced glycation end products in children receiving peritoneal dialysis with low glucose degradation product content
Nephrol. Dial. Transplant., July 1, 2007; 22(7): 2038 - 2044.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Multimed Inc. logo
Copyright © 2002 by Multimed Inc.